منابع مشابه
Decoding Melanoma Metastasis
Metastasis accounts for the vast majority of morbidity and mortality associated with melanoma. Evidence suggests melanoma has a predilection for metastasis to particular organs. Experimental analyses have begun to shed light on the mechanisms regulating melanoma metastasis and organ specificity, but these analyses are complicated by observations of metastatic dormancy and dissemination of melan...
متن کاملMelanoma Metastasis
Cancer metastasis requires a series of sequential steps, each of which is rate limiting. Neoplasms are biologically heterogeneous, and the process of metastasis is highly selective. Multiple metastases often differ in biologic characteristics and can change during the course of the disease. Clonal analysis of human melanoma suggest that systemic, physiologic signals can be recognized by neoplas...
متن کاملTonsillar melanoma metastasis.
Malignant melanoma is an aggressive cutaneous melanocytic neoplasia of fast spread1. Despite its diagnosis, the disease mortality still reaches high levels. Metastasis to the oral cavity of the cutaneous melanoma is rare2-5: until 2001 less than 30 cases of metastasis in the palatine tonsils had been published3. This type of dissemination is blood-born and the prognosis is deleterious. The reas...
متن کاملUveal Melanoma Metastasis Models.
Metastatic disease is the leading cause of death among patients with uveal melanoma. Treatment options for patients with clinically disseminated disease are usually unsuccessful. In vitro and in vivo models are important tools to investigate the pathogenesis of metastatic uveal melanomas and develop treatments for the metastases. In vitro experimental approaches focusing on cell invasion/migrat...
متن کاملMaternal melanoma with placental metastasis
A 40-year-old woman, a grand multipara with uncertain gestation, presented with severe, prolonged diarrhoea. She was previously diagnosed to have melanoma. Examination revealed gross ascites with hepatosplenomegaly and uterus corresponding to 29 weeks gestation. An emergency caesarean section confirmed widespread metastases to the ovaries, mesentery and placenta. A viable male foetus was delive...
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ژورنال
عنوان ژورنال: Cancers
سال: 2010
ISSN: 2072-6694
DOI: 10.3390/cancers3010126